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dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions
Notch signaling governs binary cell fate determination in asymmetrically dividing cells. Through a forward genetic screen we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dEHBP1) as a novel regulator of Notch signaling in asymmetrically dividing cells. d...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255984/ https://www.ncbi.nlm.nih.gov/pubmed/22213802 http://dx.doi.org/10.1083/jcb.201106088 |
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author | Giagtzoglou, Nikolaos Yamamoto, Shinya Zitserman, Diana Graves, Hillary K. Schulze, Karen L. Wang, Hao Klein, Hayley Roegiers, Fabrice Bellen, Hugo J. |
author_facet | Giagtzoglou, Nikolaos Yamamoto, Shinya Zitserman, Diana Graves, Hillary K. Schulze, Karen L. Wang, Hao Klein, Hayley Roegiers, Fabrice Bellen, Hugo J. |
author_sort | Giagtzoglou, Nikolaos |
collection | PubMed |
description | Notch signaling governs binary cell fate determination in asymmetrically dividing cells. Through a forward genetic screen we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dEHBP1) as a novel regulator of Notch signaling in asymmetrically dividing cells. dEHBP1 is enriched basally and at the actin-rich interface of pII cells of the external mechanosensory organs, where Notch signaling occurs. Loss of function of dEHBP1 leads to up-regulation of Sanpodo, a regulator of Notch signaling, and aberrant trafficking of the Notch ligand, Delta. Furthermore, Sec15 and Rab11, which have been previously shown to regulate the localization of Delta, physically interact with dEHBP1. We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Delta, thereby affecting cell fate decisions in asymmetrically dividing cells. |
format | Online Article Text |
id | pubmed-3255984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32559842012-07-09 dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions Giagtzoglou, Nikolaos Yamamoto, Shinya Zitserman, Diana Graves, Hillary K. Schulze, Karen L. Wang, Hao Klein, Hayley Roegiers, Fabrice Bellen, Hugo J. J Cell Biol Research Articles Notch signaling governs binary cell fate determination in asymmetrically dividing cells. Through a forward genetic screen we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dEHBP1) as a novel regulator of Notch signaling in asymmetrically dividing cells. dEHBP1 is enriched basally and at the actin-rich interface of pII cells of the external mechanosensory organs, where Notch signaling occurs. Loss of function of dEHBP1 leads to up-regulation of Sanpodo, a regulator of Notch signaling, and aberrant trafficking of the Notch ligand, Delta. Furthermore, Sec15 and Rab11, which have been previously shown to regulate the localization of Delta, physically interact with dEHBP1. We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Delta, thereby affecting cell fate decisions in asymmetrically dividing cells. The Rockefeller University Press 2012-01-09 /pmc/articles/PMC3255984/ /pubmed/22213802 http://dx.doi.org/10.1083/jcb.201106088 Text en © 2012 Giagtzoglou et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Giagtzoglou, Nikolaos Yamamoto, Shinya Zitserman, Diana Graves, Hillary K. Schulze, Karen L. Wang, Hao Klein, Hayley Roegiers, Fabrice Bellen, Hugo J. dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title | dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title_full | dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title_fullStr | dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title_full_unstemmed | dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title_short | dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions |
title_sort | dehbp1 controls exocytosis and recycling of delta during asymmetric divisions |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255984/ https://www.ncbi.nlm.nih.gov/pubmed/22213802 http://dx.doi.org/10.1083/jcb.201106088 |
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