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Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis

BACKGROUND: Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function...

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Autores principales: Prindaville, Brea, Rivkees, Scott A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256118/
https://www.ncbi.nlm.nih.gov/pubmed/22099887
http://dx.doi.org/10.1186/1687-9856-2011-18
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author Prindaville, Brea
Rivkees, Scott A
author_facet Prindaville, Brea
Rivkees, Scott A
author_sort Prindaville, Brea
collection PubMed
description BACKGROUND: Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function abnormalities. METHODS: A retrospective chart review was performed on 333 children who had been followed for thyroid disorders by endocrinologists at the Yale Pediatric Thyroid Center over the last 5 years for autoimmune thyroid disease. Demographical and clinical features of patients found to have thyroid disease and vitiligo were recorded. These studies were approved by the Yale Human Investigation Committee. RESULTS: Of the total 333 children and adolescents, 9 (2.7%) were noted to have vitiligo. Four patients (44%) had Graves' disease and 5 patients (66%) had Hashimoto's thyroiditis. For patients with Graves' disease and vitiligo, the average age of onset of thyroid disease was young at 4 ± 0.7 years, and the diagnosis of vitiligo usually preceded that of thyroid disease. For children with Hashimoto's thyroiditis and vitiligo, thyroid disease was diagnosed at an average age of 13.25 ± 2.8 years. CONCLUSION: In our population, 4.6% of children with Graves' disease and 2.0% of children with Hashimoto's thyroiditis had vitiligo. Interestingly, when vitiligo presents with Graves' disease, it occurs in younger rather than older children.
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spelling pubmed-32561182012-01-12 Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis Prindaville, Brea Rivkees, Scott A Int J Pediatr Endocrinol Clinical Study BACKGROUND: Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function abnormalities. METHODS: A retrospective chart review was performed on 333 children who had been followed for thyroid disorders by endocrinologists at the Yale Pediatric Thyroid Center over the last 5 years for autoimmune thyroid disease. Demographical and clinical features of patients found to have thyroid disease and vitiligo were recorded. These studies were approved by the Yale Human Investigation Committee. RESULTS: Of the total 333 children and adolescents, 9 (2.7%) were noted to have vitiligo. Four patients (44%) had Graves' disease and 5 patients (66%) had Hashimoto's thyroiditis. For patients with Graves' disease and vitiligo, the average age of onset of thyroid disease was young at 4 ± 0.7 years, and the diagnosis of vitiligo usually preceded that of thyroid disease. For children with Hashimoto's thyroiditis and vitiligo, thyroid disease was diagnosed at an average age of 13.25 ± 2.8 years. CONCLUSION: In our population, 4.6% of children with Graves' disease and 2.0% of children with Hashimoto's thyroiditis had vitiligo. Interestingly, when vitiligo presents with Graves' disease, it occurs in younger rather than older children. BioMed Central 2011 2011-11-18 /pmc/articles/PMC3256118/ /pubmed/22099887 http://dx.doi.org/10.1186/1687-9856-2011-18 Text en Copyright ©2011 Prindaville and Rivkees; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Prindaville, Brea
Rivkees, Scott A
Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title_full Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title_fullStr Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title_full_unstemmed Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title_short Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis
title_sort incidence of vitiligo in children with graves' disease and hashimoto's thyroiditis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256118/
https://www.ncbi.nlm.nih.gov/pubmed/22099887
http://dx.doi.org/10.1186/1687-9856-2011-18
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