Anti-Proteinase 3 Anti-Neutrophil Cytoplasm Autoantibodies Recapitulate Systemic Vasculitis in Mice with a Humanized Immune System

Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on mu...

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Detalles Bibliográficos
Autores principales: Little, Mark A., Al-Ani, Bahjat, Ren, Shuyu, Al-Nuaimi, Hamad, Leite, Maurilo, Alpers, Charles E., Savage, Caroline O., Duffield, Jeremy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256135/
https://www.ncbi.nlm.nih.gov/pubmed/22247758
http://dx.doi.org/10.1371/journal.pone.0028626

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