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Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function

BACKGROUND: The forkhead box transcription factor, Foxp3, is master regulator of the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. The carboxyl-terminal forkhead (FKH) domain is required for the nuclear localization and DNA b...

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Detalles Bibliográficos
Autores principales:	Liu, Yujie, Wang, Liqing, Han, Rongxiang, Beier, Ulf H., Hancock, Wayne W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256141/ https://www.ncbi.nlm.nih.gov/pubmed/22247766 http://dx.doi.org/10.1371/journal.pone.0029035

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