An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer

We investigated the effects of the matrix metalloproteinase 13 (MMP13)-selective inhibitor, 5-(4-{4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy}phenoxy)-5-(2-methoxyethyl) pyrimidine-2,4,6(1H,3H,5H)-trione (Cmpd-1), on the primary tumor growth and breast cancer-associated bone remodeling using xenog...

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Detalles Bibliográficos
Autores principales: Shah, Manisha, Huang, Dexing, Blick, Tony, Connor, Andrea, Reiter, Lawrence A., Hardink, Joel R., Lynch, Conor C., Waltham, Mark, Thompson, Erik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256168/
https://www.ncbi.nlm.nih.gov/pubmed/22253746
http://dx.doi.org/10.1371/journal.pone.0029615

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