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Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol
Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of the compound results from the elevation of reactive oxygen species (ROS) and oxidative stress to levels incompatible with cellular survival. Ho...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256171/ https://www.ncbi.nlm.nih.gov/pubmed/22253786 http://dx.doi.org/10.1371/journal.pone.0029798 |