Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome

A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address...

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Detalles Bibliográficos
Autores principales: Kim, Jayoung, Freeman, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256302/
https://www.ncbi.nlm.nih.gov/pubmed/22259731
http://dx.doi.org/10.5213/inj.2011.15.4.184
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author Kim, Jayoung
Freeman, Michael R.
author_facet Kim, Jayoung
Freeman, Michael R.
author_sort Kim, Jayoung
collection PubMed
description A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A summary of recent literature is provided, and is focused on signal transduction pathways and networks that are responsive to APF.
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spelling pubmed-32563022012-01-18 Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome Kim, Jayoung Freeman, Michael R. Int Neurourol J Review Article A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A summary of recent literature is provided, and is focused on signal transduction pathways and networks that are responsive to APF. Korean Continence Society 2011-12 2011-12-31 /pmc/articles/PMC3256302/ /pubmed/22259731 http://dx.doi.org/10.5213/inj.2011.15.4.184 Text en Copyright © 2011 Korean Continence Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (http://creativecommons.org/licenses/by-nc/3.0) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Jayoung
Freeman, Michael R.
Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title_full Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title_fullStr Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title_full_unstemmed Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title_short Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
title_sort antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256302/
https://www.ncbi.nlm.nih.gov/pubmed/22259731
http://dx.doi.org/10.5213/inj.2011.15.4.184
work_keys_str_mv AT kimjayoung antiproliferativefactorsignalingandinterstitialcystitispainfulbladdersyndrome
AT freemanmichaelr antiproliferativefactorsignalingandinterstitialcystitispainfulbladdersyndrome

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