Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

TDP-43 (TAR DNA-binding protein 43) inclusions are a hallmark of amyotrophic lateral sclerosis (ALS). In this study, we report that TDP-43 and nuclear factor κB (NF-κB) p65 messenger RNA and protein expression is higher in spinal cords in ALS patients than healthy individuals. TDP-43 interacts with...

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Detalles Bibliográficos
Autores principales: Swarup, Vivek, Phaneuf, Daniel, Dupré, Nicolas, Petri, Susanne, Strong, Michael, Kriz, Jasna, Julien, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256969/
https://www.ncbi.nlm.nih.gov/pubmed/22084410
http://dx.doi.org/10.1084/jem.20111313

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