Cargando…

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development of human HSCs. We demonstrate that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the dorsal aorta, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ivanovs, Andrejs, Rybtsov, Stanislav, Welch, Lindsey, Anderson, Richard A., Turner, Marc L., Medvinsky, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256972/ https://www.ncbi.nlm.nih.gov/pubmed/22042975 http://dx.doi.org/10.1084/jem.20111688

Ejemplares similares

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells
por: Ivanovs, Andrejs, et al.
Publicado: (2014)

Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta‐Gonad‐Mesonephros Region
por: Wang, Haizhen, et al.
Publicado: (2023)

Vast Self-Renewal Potential of Human AGM Region HSCs Dramatically Declines in the Umbilical Cord Blood
por: Ivanovs, Andrejs, et al.
Publicado: (2020)

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival
por: Lv, Junhua, et al.
Publicado: (2017)

Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver
por: Rybtsov, Stanislav, et al.
Publicado: (2016)

Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo
por: Easterbrook, Jennifer, et al.
Publicado: (2019)

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region
por: Rybtsov, Stanislav, et al.
Publicado: (2011)

Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation
por: Nobuhisa, Ikuo, et al.
Publicado: (2004)

Kit ligand has a critical role in mouse yolk sac and aorta–gonad–mesonephros hematopoiesis
por: Azzoni, Emanuele, et al.
Publicado: (2018)

Evolutionary intraembryonic origin of vertebrate hematopoietic stem cells in the elasmobranch spleen
por: Manca, Rosa, et al.
Publicado: (2018)

Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro
por: Marshall, Caroline J, et al.
Publicado: (2007)

Morphology and immunolocalization of intertubular steroidogenic cell in mesonephros of Podocnemis expansa during gonadal differentiation
por: de Macêdo, Luã Barbalho, et al.
Publicado: (2022)

Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis
por: Gomes Fernandes, Maria, et al.
Publicado: (2018)

Stem Cell Emergence and Hemopoietic Activity Are Incompatible in Mouse Intraembryonic Sites
por: Godin, Isabelle, et al.
Publicado: (1999)

Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture
por: Batsivari, Antoniana, et al.
Publicado: (2017)

Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System
por: Jackson, Melany, et al.
Publicado: (2021)

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development
por: Crosse, Edie I., et al.
Publicado: (2020)

Hematopoietic Stem Cells and the Immune System in Development and Aging
por: Shevyrev, Daniil, et al.
Publicado: (2023)

Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43(−) Embryonic Precursor
por: Rybtsov, Stanislav, et al.
Publicado: (2014)

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation
por: McGarvey, Alison C., et al.
Publicado: (2017)

STUDIES CONCERNING THE SITE OF RENIN FORMATION IN THE KIDNEY : III. THE APPARENT SITE OF RENIN FORMATION IN THE TUBULES OF THE MESONEPHROS AND METANEPHROS OF THE HOG FETUS
por: Kaplan, A., et al.
Publicado: (1942)

Endothelio-hematopoietic relationship: getting closer to the beginnings
por: Gordon-Keylock, Sabrina, et al.
Publicado: (2011)

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach
por: Senserrich, Jordi, et al.
Publicado: (2018)

Directed Differentiation of Embryonic Stem Cells Using a Bead-Based Combinatorial Screening Method
por: Tarunina, Marina, et al.
Publicado: (2014)

Loneliness, social isolation and ageing: a methodological approach to compare Latvian and Icelandic older populations in the course of COVID-19 pandemic
por: Reine, Ieva, et al.
Publicado: (2023)

Construction of healthy aging index from two different datasets
por: Miķelsone, Madara, et al.
Publicado: (2023)

Runx1 is required for progression of CD41(+) embryonic precursors into HSCs but not prior to this
por: Liakhovitskaia, Anna, et al.
Publicado: (2014)

PMON69 Effective Suppression of Gonadotropins and Gonadal Steroids Following Oral Administration of Leuprolide
por: Shangold, Gary, et al.
Publicado: (2022)

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
por: Souilhol, Céline, et al.
Publicado: (2016)

Gonadal function in pediatric Fanconi anemia patients treated with hematopoietic stem cell transplant
por: Koo, Jane, et al.
Publicado: (2023)

Deciphering the Stromal and Hematopoietic Cell Network of the Adventitia from Non-Aneurysmal and Aneurysmal Human Aorta
por: Dutertre, Charles-Antoine, et al.
Publicado: (2014)

Acceleration of Biological Aging and Underestimation of Subjective Age Are Risk Factors for Severe COVID-19
por: Berezina, Tatiana N., et al.
Publicado: (2021)

The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells
por: Tian, Ye, et al.
Publicado: (2017)

Use of Personal Resources May Influence the Rate of Biological Aging Depending on Individual Typology
por: Berezina, Tatiana N., et al.
Publicado: (2022)

The levels of apostosis markers in different HIV infected patients groups
por: Sondore, Eksteina Ilze, et al.
Publicado: (2012)

Problems of HIV positive tuberculosis patients' health care in Latvia
por: Viksna, Ludmila, et al.
Publicado: (2012)

Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases
por: Sutani, Akito, et al.
Publicado: (2019)

Molecular Markers of Blood Cell Populations Can Help Estimate Aging of the Immune System
por: Rybtsova, Natalia, et al.
Publicado: (2023)

Digenesia gonadal
por: Barbosa Carmona, Manuel
Publicado: (1998)

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells
por: Mariani, Samanta Antonella, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7o35gmec40mpkvgs90njnn42pb