Identification of a central role for complement in osteoarthritis

Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of “wear and tear”(1). Although low-grade inflammation is detected in osteoarthritis, its role is unclear(2–4). Here we identify a central role for the inflammatory complement...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Rozelle, Andrew L., Lepus, Christin M., Scanzello, Carla R., Song, Jason J., Larsen, D. Meegan, Crish, James F., Bebek, Gurkan, Ritter, Susan Y., Lindstrom, Tamsin M., Hwang, Inyong, Wong, Heidi H., Punzi, Leonardo, Encarnacion, Angelo, Shamloo, Mehrdad, Goodman, Stuart B., Wyss-Coray, Tony, Goldring, Steven R., Banda, Nirmal K., Thurman, Joshua M., Gobezie, Reuben, Crow, Mary K., Holers, V. Michael, Lee, David M., Robinson, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257059/
https://www.ncbi.nlm.nih.gov/pubmed/22057346
http://dx.doi.org/10.1038/nm.2543

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