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The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice

The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw...

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Autores principales: Gu, Chunmei, Qu, Hongsheng, Han, Lingling, Song, Xinxiu, Zhao, Linlin, Lu, Wenfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257103/
https://www.ncbi.nlm.nih.gov/pubmed/22272106
http://dx.doi.org/10.3390/ijms12128836
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author Gu, Chunmei
Qu, Hongsheng
Han, Lingling
Song, Xinxiu
Zhao, Linlin
Lu, Wenfa
author_facet Gu, Chunmei
Qu, Hongsheng
Han, Lingling
Song, Xinxiu
Zhao, Linlin
Lu, Wenfa
author_sort Gu, Chunmei
collection PubMed
description The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw soybean diet and Group 3 was fed on raw soybean diet supplemented with 30 mg/kg cysteamine. After two weeks of feeding, duodenum, liver and pancreas samples were collected to measure oxidative and antioxidative parameters. The results show that ingestion of raw soybean markedly increased contents of superoxide anion and malondialdehyde (MDA) and activity of inducible nitric oxide synthase (iNOS), decreased activity of superoxide dismutase (SOD), T-AOC and content of reduced glutathione (GSH) in digestive organs of mice (P < 0.05). In the group fed with raw soybean diet supplemented with cysteamine, oxidative stress was mitigated. However, oxidative parameter levels were still higher than those of control diet-fed group. The present study indicates that ingestion of raw soybean could result in an imbalance between oxidant and antioxidant, and thus induce oxidative stress in digestive organs of mice.
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spelling pubmed-32571032012-01-23 The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice Gu, Chunmei Qu, Hongsheng Han, Lingling Song, Xinxiu Zhao, Linlin Lu, Wenfa Int J Mol Sci Article The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw soybean diet and Group 3 was fed on raw soybean diet supplemented with 30 mg/kg cysteamine. After two weeks of feeding, duodenum, liver and pancreas samples were collected to measure oxidative and antioxidative parameters. The results show that ingestion of raw soybean markedly increased contents of superoxide anion and malondialdehyde (MDA) and activity of inducible nitric oxide synthase (iNOS), decreased activity of superoxide dismutase (SOD), T-AOC and content of reduced glutathione (GSH) in digestive organs of mice (P < 0.05). In the group fed with raw soybean diet supplemented with cysteamine, oxidative stress was mitigated. However, oxidative parameter levels were still higher than those of control diet-fed group. The present study indicates that ingestion of raw soybean could result in an imbalance between oxidant and antioxidant, and thus induce oxidative stress in digestive organs of mice. Molecular Diversity Preservation International (MDPI) 2011-12-02 /pmc/articles/PMC3257103/ /pubmed/22272106 http://dx.doi.org/10.3390/ijms12128836 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gu, Chunmei
Qu, Hongsheng
Han, Lingling
Song, Xinxiu
Zhao, Linlin
Lu, Wenfa
The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title_full The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title_fullStr The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title_full_unstemmed The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title_short The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice
title_sort effect of raw soybean on oxidative status of digestive organs in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257103/
https://www.ncbi.nlm.nih.gov/pubmed/22272106
http://dx.doi.org/10.3390/ijms12128836
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