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New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves
The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257113/ https://www.ncbi.nlm.nih.gov/pubmed/22272116 http://dx.doi.org/10.3390/ijms12128993 |
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author | da Silva, Jucélia Barbosa Temponi, Vanessa dos Santos Fernandes, Felipe Valente de Assis Dias Alves, Geórgia de Matos, Dalyara Mendonça Gasparetto, Carolina Miranda Ribeiro, Antônia de Pinho, José de Jesus R. G. Alves, Maria Silvana de Sousa, Orlando Vieira |
author_facet | da Silva, Jucélia Barbosa Temponi, Vanessa dos Santos Fernandes, Felipe Valente de Assis Dias Alves, Geórgia de Matos, Dalyara Mendonça Gasparetto, Carolina Miranda Ribeiro, Antônia de Pinho, José de Jesus R. G. Alves, Maria Silvana de Sousa, Orlando Vieira |
author_sort | da Silva, Jucélia Barbosa |
collection | PubMed |
description | The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved. |
format | Online Article Text |
id | pubmed-3257113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32571132012-01-23 New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves da Silva, Jucélia Barbosa Temponi, Vanessa dos Santos Fernandes, Felipe Valente de Assis Dias Alves, Geórgia de Matos, Dalyara Mendonça Gasparetto, Carolina Miranda Ribeiro, Antônia de Pinho, José de Jesus R. G. Alves, Maria Silvana de Sousa, Orlando Vieira Int J Mol Sci Article The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved. Molecular Diversity Preservation International (MDPI) 2011-12-07 /pmc/articles/PMC3257113/ /pubmed/22272116 http://dx.doi.org/10.3390/ijms12128993 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article da Silva, Jucélia Barbosa Temponi, Vanessa dos Santos Fernandes, Felipe Valente de Assis Dias Alves, Geórgia de Matos, Dalyara Mendonça Gasparetto, Carolina Miranda Ribeiro, Antônia de Pinho, José de Jesus R. G. Alves, Maria Silvana de Sousa, Orlando Vieira New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title | New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title_full | New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title_fullStr | New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title_full_unstemmed | New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title_short | New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves |
title_sort | new approaches to clarify antinociceptive and anti-inflammatory effects of the ethanol extract from vernonia condensata leaves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257113/ https://www.ncbi.nlm.nih.gov/pubmed/22272116 http://dx.doi.org/10.3390/ijms12128993 |
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