Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method

MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshizawa, Masato, Taguchi, Y-h., Yasuda, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257129/
https://www.ncbi.nlm.nih.gov/pubmed/22272132
http://dx.doi.org/10.3390/ijms12129265
_version_ 1782221109963259904
author Yoshizawa, Masato
Taguchi, Y-h.
Yasuda, Jun
author_facet Yoshizawa, Masato
Taguchi, Y-h.
Yasuda, Jun
author_sort Yoshizawa, Masato
collection PubMed
description MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.
format Online
Article
Text
id pubmed-3257129
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-32571292012-01-23 Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method Yoshizawa, Masato Taguchi, Y-h. Yasuda, Jun Int J Mol Sci Article MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells. Molecular Diversity Preservation International (MDPI) 2011-12-12 /pmc/articles/PMC3257129/ /pubmed/22272132 http://dx.doi.org/10.3390/ijms12129265 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yoshizawa, Masato
Taguchi, Y-h.
Yasuda, Jun
Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title_full Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title_fullStr Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title_full_unstemmed Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title_short Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method
title_sort inference of gene regulation via mirnas during es cell differentiation using mirage method
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257129/
https://www.ncbi.nlm.nih.gov/pubmed/22272132
http://dx.doi.org/10.3390/ijms12129265
work_keys_str_mv AT yoshizawamasato inferenceofgeneregulationviamirnasduringescelldifferentiationusingmiragemethod
AT taguchiyh inferenceofgeneregulationviamirnasduringescelldifferentiationusingmiragemethod
AT yasudajun inferenceofgeneregulationviamirnasduringescelldifferentiationusingmiragemethod

Ejemplares similares