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Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer

Colorectal cancer is a major health burden, and a leading cause of cancer-related deaths in industrialized countries. The steady improvements in surgery and chemotherapy have improved survival, but the ability to identify high- and low-risk patients is still somewhat poor. Molecular biology has, ove...

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Detalles Bibliográficos
Autores principales: Berg, Marianne, Søreide, Kjetil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257138/
https://www.ncbi.nlm.nih.gov/pubmed/22272141
http://dx.doi.org/10.3390/ijms12129426
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author Berg, Marianne
Søreide, Kjetil
author_facet Berg, Marianne
Søreide, Kjetil
author_sort Berg, Marianne
collection PubMed
description Colorectal cancer is a major health burden, and a leading cause of cancer-related deaths in industrialized countries. The steady improvements in surgery and chemotherapy have improved survival, but the ability to identify high- and low-risk patients is still somewhat poor. Molecular biology has, over the years, given insight into basic principles of colorectal cancer initiation and development. These findings include aberrations increasing risk of tumor development, genetic changes associated with the stepwise progression of the disease, and errors predicting response to a specific treatment. Potential biomarkers in colorectal cancer are extensively studied, and how the molecular aberrations relate to clinical features. Yet, little of this knowledge has been possible to transfer into clinical practice. In this review, an overview of colorectal cancer genetics will be given, as well as how aberrations found in this tumor type are proposed as biomarkers for risk prediction, as diagnostic tools, for prognosis or prediction of treatment outcome.
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spelling pubmed-32571382012-01-23 Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer Berg, Marianne Søreide, Kjetil Int J Mol Sci Review Colorectal cancer is a major health burden, and a leading cause of cancer-related deaths in industrialized countries. The steady improvements in surgery and chemotherapy have improved survival, but the ability to identify high- and low-risk patients is still somewhat poor. Molecular biology has, over the years, given insight into basic principles of colorectal cancer initiation and development. These findings include aberrations increasing risk of tumor development, genetic changes associated with the stepwise progression of the disease, and errors predicting response to a specific treatment. Potential biomarkers in colorectal cancer are extensively studied, and how the molecular aberrations relate to clinical features. Yet, little of this knowledge has been possible to transfer into clinical practice. In this review, an overview of colorectal cancer genetics will be given, as well as how aberrations found in this tumor type are proposed as biomarkers for risk prediction, as diagnostic tools, for prognosis or prediction of treatment outcome. Molecular Diversity Preservation International (MDPI) 2011-12-16 /pmc/articles/PMC3257138/ /pubmed/22272141 http://dx.doi.org/10.3390/ijms12129426 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Berg, Marianne
Søreide, Kjetil
Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title_full Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title_fullStr Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title_full_unstemmed Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title_short Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
title_sort genetic and epigenetic traits as biomarkers in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257138/
https://www.ncbi.nlm.nih.gov/pubmed/22272141
http://dx.doi.org/10.3390/ijms12129426
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