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Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling

Human cancers often contain genetic alterations that disable G1/S checkpoint control and loss of this checkpoint is thought to critically contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle exit. The identification of cell permeable small m...

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Detalles Bibliográficos
Autores principales:	Stockwell, Simon R., Platt, Georgina, Barrie, S. Elaine, Zoumpoulidou, Georgia, te Poele, Robert H., Aherne, G. Wynne, Wilson, Stuart C., Sheldrake, Peter, McDonald, Edward, Venet, Mathilde, Soudy, Christelle, Elustondo, Frédéric, Rigoreau, Laurent, Blagg, Julian, Workman, Paul, Garrett, Michelle D., Mittnacht, Sibylle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257223/ https://www.ncbi.nlm.nih.gov/pubmed/22253692 http://dx.doi.org/10.1371/journal.pone.0028568

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