Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury

Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of...

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Autores principales: Dittgen, Tanjew, Pitzer, Claudia, Plaas, Christian, Kirsch, Friederike, Vogt, Gerhard, Laage, Rico, Schneider, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257226/
https://www.ncbi.nlm.nih.gov/pubmed/22253813
http://dx.doi.org/10.1371/journal.pone.0029880
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author Dittgen, Tanjew
Pitzer, Claudia
Plaas, Christian
Kirsch, Friederike
Vogt, Gerhard
Laage, Rico
Schneider, Armin
author_facet Dittgen, Tanjew
Pitzer, Claudia
Plaas, Christian
Kirsch, Friederike
Vogt, Gerhard
Laage, Rico
Schneider, Armin
author_sort Dittgen, Tanjew
collection PubMed
description Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.
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spelling pubmed-32572262012-01-17 Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury Dittgen, Tanjew Pitzer, Claudia Plaas, Christian Kirsch, Friederike Vogt, Gerhard Laage, Rico Schneider, Armin PLoS One Research Article Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function. Public Library of Science 2012-01-12 /pmc/articles/PMC3257226/ /pubmed/22253813 http://dx.doi.org/10.1371/journal.pone.0029880 Text en Dittgen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dittgen, Tanjew
Pitzer, Claudia
Plaas, Christian
Kirsch, Friederike
Vogt, Gerhard
Laage, Rico
Schneider, Armin
Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title_full Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title_fullStr Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title_full_unstemmed Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title_short Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury
title_sort granulocyte-colony stimulating factor (g-csf) improves motor recovery in the rat impactor model for spinal cord injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257226/
https://www.ncbi.nlm.nih.gov/pubmed/22253813
http://dx.doi.org/10.1371/journal.pone.0029880
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