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NMR Studies on Structure and Dynamics of the Monomeric Derivative of BS-RNase: New Insights for 3D Domain Swapping
Three-dimensional domain swapping is a common phenomenon in pancreatic-like ribonucleases. In the aggregated state, these proteins acquire new biological functions, including selective cytotoxicity against tumour cells. RNase A is able to dislocate both N- and C-termini, but usually this process req...
Autores principales: | Spadaccini, Roberta, Ercole, Carmine, Gentile, Maria A., Sanfelice, Domenico, Boelens, Rolf, Wechselberger, Rainer, Batta, Gyula, Bernini, Andrea, Niccolai, Neri, Picone, Delia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257227/ https://www.ncbi.nlm.nih.gov/pubmed/22253705 http://dx.doi.org/10.1371/journal.pone.0029076 |
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