A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune...

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Detalles Bibliográficos
Autores principales: Guerini, Franca Rosa, Cagliani, Rachele, Forni, Diego, Agliardi, Cristina, Caputo, Domenico, Cassinotti, Andrea, Galimberti, Daniela, Fenoglio, Chiara, Biasin, Mara, Asselta, Rosanna, Scarpini, Elio, Comi, Giacomo P., Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257233/
https://www.ncbi.nlm.nih.gov/pubmed/22253828
http://dx.doi.org/10.1371/journal.pone.0029931

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