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Crystal Structure of a Human Single Domain Antibody Dimer Formed through V(H)-V(H) Non-Covalent Interactions

Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes it difficult to determine the crystal structures. In this study, we isolated and characterized two anti-human epidermal growth factor receptor-2 (HER2) sdAbs, Gr3 and Gr6, fr...

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Detalles Bibliográficos
Autores principales:	Baral, Toya Nath, Chao, Shi-Yu, Li, Shenghua, Tanha, Jamshid, Arbabi-Ghahroudi, Mehdi, Zhang, Jianbing, Wang, Shuying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257273/ https://www.ncbi.nlm.nih.gov/pubmed/22253912 http://dx.doi.org/10.1371/journal.pone.0030149

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