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Snorkeling Basic Amino Acid Side Chains Regulate Transmembrane Integrin Signalling
Side chains of Lys/Arg near transmembrane domain (TMD)(1–3) membrane-water interfaces can “snorkel” placing their positive charge near negatively-charged phospholipid head groups(4–6); however, snorkeling's functional effects are obscure. Integrin β TMDs exhibit such conserved basic amino acids...
Autores principales: | Kim, Chungho, Schmidt, Thomas, Cho, Eun-Gyung, Ye, Feng, Ulmer, Tobias S., Ginsberg, Mark H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257387/ https://www.ncbi.nlm.nih.gov/pubmed/22178926 http://dx.doi.org/10.1038/nature10697 |
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