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Snorkeling Basic Amino Acid Side Chains Regulate Transmembrane Integrin Signalling

Side chains of Lys/Arg near transmembrane domain (TMD)(1–3) membrane-water interfaces can “snorkel” placing their positive charge near negatively-charged phospholipid head groups(4–6); however, snorkeling's functional effects are obscure. Integrin β TMDs exhibit such conserved basic amino acids...

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Detalles Bibliográficos
Autores principales:	Kim, Chungho, Schmidt, Thomas, Cho, Eun-Gyung, Ye, Feng, Ulmer, Tobias S., Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257387/ https://www.ncbi.nlm.nih.gov/pubmed/22178926 http://dx.doi.org/10.1038/nature10697

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