Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)(1–3). In neurons, the paternal allele of Ube3a is intact but epigenetically silenced(4–6), raising the possibility that Angelman syndrome could...

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Detalles Bibliográficos
Autores principales: Huang, Hsien-Sung, Allen, John A., Mabb, Angela M., King, Ian F., Miriyala, JayaLakshmi, Taylor-Blake, Bonnie, Sciaky, Noah, Dutton, J. Walter, Lee, Hyeong-Min, Chen, Xin, Jin, Jian, Bridges, Arlene S., Zylka, Mark J., Roth, Bryan L., Philpot, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257422/
https://www.ncbi.nlm.nih.gov/pubmed/22190039
http://dx.doi.org/10.1038/nature10726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257422/
https://www.ncbi.nlm.nih.gov/pubmed/22190039
http://dx.doi.org/10.1038/nature10726

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