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Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)(1–3). In neurons, the paternal allele of Ube3a is intact but epigenetically silenced(4–6), raising the possibility that Angelman syndrome could...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257422/ https://www.ncbi.nlm.nih.gov/pubmed/22190039 http://dx.doi.org/10.1038/nature10726 |