Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

Using a screen for Wnt/β-catenin inhibitors, a family of 8-hydroxyquinolone derivatives with in vivo anti-cancer properties was identified. Analysis of microarray data for the lead compound N-((8-hydroxy-7-quinolinyl) (4-methylphenyl)methyl)benzamide (HQBA) using the Connectivity Map database sugges...

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Detalles Bibliográficos
Autores principales: Coombs, G S, Schmitt, A A, Canning, C A, Alok, A, Low, I C C, Banerjee, N, Kaur, S, Utomo, V, Jones, C M, Pervaiz, S, Toone, E J, Virshup, D M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257471/
https://www.ncbi.nlm.nih.gov/pubmed/21666721
http://dx.doi.org/10.1038/onc.2011.228

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