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E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells
Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metasta...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257573/ https://www.ncbi.nlm.nih.gov/pubmed/22105347 http://dx.doi.org/10.1083/jcb.201106023 |
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author | Straub, Beate K. Rickelt, Steffen Zimbelmann, Ralf Grund, Christine Kuhn, Caecilia Iken, Marcus Ott, Michael Schirmacher, Peter Franke, Werner W. |
author_facet | Straub, Beate K. Rickelt, Steffen Zimbelmann, Ralf Grund, Christine Kuhn, Caecilia Iken, Marcus Ott, Michael Schirmacher, Peter Franke, Werner W. |
author_sort | Straub, Beate K. |
collection | PubMed |
description | Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this “cadherin switch” hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E–N heterodimers. We also show that cells possessing E–N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin–based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered. |
format | Online Article Text |
id | pubmed-3257573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32575732012-05-28 E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells Straub, Beate K. Rickelt, Steffen Zimbelmann, Ralf Grund, Christine Kuhn, Caecilia Iken, Marcus Ott, Michael Schirmacher, Peter Franke, Werner W. J Cell Biol Research Articles Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this “cadherin switch” hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E–N heterodimers. We also show that cells possessing E–N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin–based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered. The Rockefeller University Press 2011-11-28 /pmc/articles/PMC3257573/ /pubmed/22105347 http://dx.doi.org/10.1083/jcb.201106023 Text en © 2011 Straub et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Straub, Beate K. Rickelt, Steffen Zimbelmann, Ralf Grund, Christine Kuhn, Caecilia Iken, Marcus Ott, Michael Schirmacher, Peter Franke, Werner W. E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title_full | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title_fullStr | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title_full_unstemmed | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title_short | E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
title_sort | e–n-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257573/ https://www.ncbi.nlm.nih.gov/pubmed/22105347 http://dx.doi.org/10.1083/jcb.201106023 |
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