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Ajuba is required for Rac activation and maintenance of E-cadherin adhesion

Maintenance of stable E-cadherin–dependent adhesion is essential for epithelial function. The small GTPase Rac is activated by initial cadherin clustering, but the precise mechanisms underlying Rac-dependent junction stabilization are not well understood. Ajuba, a LIM domain protein, colocalizes wit...

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Detalles Bibliográficos
Autores principales: Nola, Sébastien, Daigaku, Reiko, Smolarczyk, Kasia, Carstens, Maryke, Martin-Martin, Belen, Longmore, Gregory, Bailly, Maryse, Braga, Vania M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257575/
https://www.ncbi.nlm.nih.gov/pubmed/22105346
http://dx.doi.org/10.1083/jcb.201107162