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Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature
Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257613/ https://www.ncbi.nlm.nih.gov/pubmed/22253993 http://dx.doi.org/10.3390/nu2010075 |
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author | Culbertson, Julie Y. Kreider, Richard B. Greenwood, Mike Cooke, Matthew |
author_facet | Culbertson, Julie Y. Kreider, Richard B. Greenwood, Mike Cooke, Matthew |
author_sort | Culbertson, Julie Y. |
collection | PubMed |
description | Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to increase carnosine concentrations in skeletal muscle by 20-80%. Several studies have reported that β-ALA supplementation can increase high-intensity intermittent exercise performance and/or training adaptations. Although the specific mechanism remains to be determined, the ergogenicity of β-ALA has been most commonly attributed to an increased muscle buffering capacity. More recently, researchers have investigated the effects of co-ingesting β-ALA with creatine monohydrate to determine whether there may be synergistic and/or additive benefits. This paper overviews the theoretical rationale and potential ergogenic value of β-ALA supplementation with or without creatine as well as provides future research recommendations. |
format | Online Article Text |
id | pubmed-3257613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-32576132012-01-17 Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature Culbertson, Julie Y. Kreider, Richard B. Greenwood, Mike Cooke, Matthew Nutrients Review Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to increase carnosine concentrations in skeletal muscle by 20-80%. Several studies have reported that β-ALA supplementation can increase high-intensity intermittent exercise performance and/or training adaptations. Although the specific mechanism remains to be determined, the ergogenicity of β-ALA has been most commonly attributed to an increased muscle buffering capacity. More recently, researchers have investigated the effects of co-ingesting β-ALA with creatine monohydrate to determine whether there may be synergistic and/or additive benefits. This paper overviews the theoretical rationale and potential ergogenic value of β-ALA supplementation with or without creatine as well as provides future research recommendations. Molecular Diversity Preservation International 2010-01-25 /pmc/articles/PMC3257613/ /pubmed/22253993 http://dx.doi.org/10.3390/nu2010075 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Culbertson, Julie Y. Kreider, Richard B. Greenwood, Mike Cooke, Matthew Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title | Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title_full | Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title_fullStr | Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title_full_unstemmed | Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title_short | Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature |
title_sort | effects of beta-alanine on muscle carnosine and exercise performance:a review of the current literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257613/ https://www.ncbi.nlm.nih.gov/pubmed/22253993 http://dx.doi.org/10.3390/nu2010075 |
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