The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)

This study compared serum pyridine levels (NAD(+ )/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17%...

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Detalles Bibliográficos
Autores principales: Mach, John, Midgley, Adrian W., Dank, Steve, Grant, Ross S., Bentley, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257644/
https://www.ncbi.nlm.nih.gov/pubmed/22254024
http://dx.doi.org/10.3390/nu2030319
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author Mach, John
Midgley, Adrian W.
Dank, Steve
Grant, Ross S.
Bentley, David J.
author_facet Mach, John
Midgley, Adrian W.
Dank, Steve
Grant, Ross S.
Bentley, David J.
author_sort Mach, John
collection PubMed
description This study compared serum pyridine levels (NAD(+ )/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD(+) levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD(+) and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
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spelling pubmed-32576442012-01-17 The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H) Mach, John Midgley, Adrian W. Dank, Steve Grant, Ross S. Bentley, David J. Nutrients Article This study compared serum pyridine levels (NAD(+ )/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD(+) levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD(+) and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration. Molecular Diversity Preservation International 2010-03-10 /pmc/articles/PMC3257644/ /pubmed/22254024 http://dx.doi.org/10.3390/nu2030319 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mach, John
Midgley, Adrian W.
Dank, Steve
Grant, Ross S.
Bentley, David J.
The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title_full The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title_fullStr The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title_full_unstemmed The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title_short The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)
title_sort effect of antioxidant supplementation on fatigue during exercise: potential role for nad(+)(h)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257644/
https://www.ncbi.nlm.nih.gov/pubmed/22254024
http://dx.doi.org/10.3390/nu2030319
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