Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea

We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interl...

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Autores principales: Vaisman, Nachum, Press, Josef, Leibovitz, Eugene, Boehm, Güenther, Barak, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257680/
https://www.ncbi.nlm.nih.gov/pubmed/22254048
http://dx.doi.org/10.3390/nu2070683
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author Vaisman, Nachum
Press, Josef
Leibovitz, Eugene
Boehm, Güenther
Barak, Vivian
author_facet Vaisman, Nachum
Press, Josef
Leibovitz, Eugene
Boehm, Güenther
Barak, Vivian
author_sort Vaisman, Nachum
collection PubMed
description We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.
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spelling pubmed-32576802012-01-17 Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea Vaisman, Nachum Press, Josef Leibovitz, Eugene Boehm, Güenther Barak, Vivian Nutrients Article We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course. MDPI 2010-06-30 /pmc/articles/PMC3257680/ /pubmed/22254048 http://dx.doi.org/10.3390/nu2070683 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Vaisman, Nachum
Press, Josef
Leibovitz, Eugene
Boehm, Güenther
Barak, Vivian
Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title_full Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title_fullStr Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title_full_unstemmed Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title_short Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
title_sort short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257680/
https://www.ncbi.nlm.nih.gov/pubmed/22254048
http://dx.doi.org/10.3390/nu2070683
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