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Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract
Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, blood pressure, bone metabolism and immune function. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257691/ https://www.ncbi.nlm.nih.gov/pubmed/22254112 http://dx.doi.org/10.3390/nu3050574 |
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author | Jahan-Mihan, Alireza Luhovyy, Bohdan L. Khoury, Dalia El Anderson, G. Harvey |
author_facet | Jahan-Mihan, Alireza Luhovyy, Bohdan L. Khoury, Dalia El Anderson, G. Harvey |
author_sort | Jahan-Mihan, Alireza |
collection | PubMed |
description | Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, blood pressure, bone metabolism and immune function. The interaction of dietary proteins and their products of digestion with the regulatory functions of the gastrointestinal (GI) tract plays a dominant role in determining the physiological properties of proteins. The site of interaction is widespread, from the oral cavity to the colon. The characteristics of proteins that influence their interaction with the GI tract in a source-dependent manner include their physico-chemical properties, their amino acid composition and sequence, their bioactive peptides, their digestion kinetics and also the non-protein bioactive components conjugated with them. Within the GI tract, these products affect several regulatory functions by interacting with receptors releasing hormones, affecting stomach emptying and GI transport and absorption, transmitting neural signals to the brain, and modifying the microflora. This review discusses the interaction of dietary proteins during digestion and absorption with the physiological and metabolic functions of the GI tract, and illustrates the importance of this interaction in the regulation of amino acid, glucose, lipid metabolism, and food intake. |
format | Online Article Text |
id | pubmed-3257691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-32576912012-01-17 Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract Jahan-Mihan, Alireza Luhovyy, Bohdan L. Khoury, Dalia El Anderson, G. Harvey Nutrients Review Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, blood pressure, bone metabolism and immune function. The interaction of dietary proteins and their products of digestion with the regulatory functions of the gastrointestinal (GI) tract plays a dominant role in determining the physiological properties of proteins. The site of interaction is widespread, from the oral cavity to the colon. The characteristics of proteins that influence their interaction with the GI tract in a source-dependent manner include their physico-chemical properties, their amino acid composition and sequence, their bioactive peptides, their digestion kinetics and also the non-protein bioactive components conjugated with them. Within the GI tract, these products affect several regulatory functions by interacting with receptors releasing hormones, affecting stomach emptying and GI transport and absorption, transmitting neural signals to the brain, and modifying the microflora. This review discusses the interaction of dietary proteins during digestion and absorption with the physiological and metabolic functions of the GI tract, and illustrates the importance of this interaction in the regulation of amino acid, glucose, lipid metabolism, and food intake. MDPI 2011-05-11 /pmc/articles/PMC3257691/ /pubmed/22254112 http://dx.doi.org/10.3390/nu3050574 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Jahan-Mihan, Alireza Luhovyy, Bohdan L. Khoury, Dalia El Anderson, G. Harvey Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title | Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title_full | Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title_fullStr | Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title_full_unstemmed | Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title_short | Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract |
title_sort | dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257691/ https://www.ncbi.nlm.nih.gov/pubmed/22254112 http://dx.doi.org/10.3390/nu3050574 |
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