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Flavonoids: Antioxidants Against Atherosclerosis
Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257706/ https://www.ncbi.nlm.nih.gov/pubmed/22254061 http://dx.doi.org/10.3390/nu2080889 |
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author | Grassi, Davide Desideri, Giovambattista Ferri, Claudio |
author_facet | Grassi, Davide Desideri, Giovambattista Ferri, Claudio |
author_sort | Grassi, Davide |
collection | PubMed |
description | Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability. |
format | Online Article Text |
id | pubmed-3257706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-32577062012-01-17 Flavonoids: Antioxidants Against Atherosclerosis Grassi, Davide Desideri, Giovambattista Ferri, Claudio Nutrients Review Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability. MDPI 2010-08-12 /pmc/articles/PMC3257706/ /pubmed/22254061 http://dx.doi.org/10.3390/nu2080889 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Grassi, Davide Desideri, Giovambattista Ferri, Claudio Flavonoids: Antioxidants Against Atherosclerosis |
title | Flavonoids: Antioxidants Against Atherosclerosis |
title_full | Flavonoids: Antioxidants Against Atherosclerosis |
title_fullStr | Flavonoids: Antioxidants Against Atherosclerosis |
title_full_unstemmed | Flavonoids: Antioxidants Against Atherosclerosis |
title_short | Flavonoids: Antioxidants Against Atherosclerosis |
title_sort | flavonoids: antioxidants against atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257706/ https://www.ncbi.nlm.nih.gov/pubmed/22254061 http://dx.doi.org/10.3390/nu2080889 |
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