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Flavonoids: Antioxidants Against Atherosclerosis

Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO,...

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Detalles Bibliográficos
Autores principales: Grassi, Davide, Desideri, Giovambattista, Ferri, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257706/
https://www.ncbi.nlm.nih.gov/pubmed/22254061
http://dx.doi.org/10.3390/nu2080889
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author Grassi, Davide
Desideri, Giovambattista
Ferri, Claudio
author_facet Grassi, Davide
Desideri, Giovambattista
Ferri, Claudio
author_sort Grassi, Davide
collection PubMed
description Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability.
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spelling pubmed-32577062012-01-17 Flavonoids: Antioxidants Against Atherosclerosis Grassi, Davide Desideri, Giovambattista Ferri, Claudio Nutrients Review Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability. MDPI 2010-08-12 /pmc/articles/PMC3257706/ /pubmed/22254061 http://dx.doi.org/10.3390/nu2080889 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Grassi, Davide
Desideri, Giovambattista
Ferri, Claudio
Flavonoids: Antioxidants Against Atherosclerosis
title Flavonoids: Antioxidants Against Atherosclerosis
title_full Flavonoids: Antioxidants Against Atherosclerosis
title_fullStr Flavonoids: Antioxidants Against Atherosclerosis
title_full_unstemmed Flavonoids: Antioxidants Against Atherosclerosis
title_short Flavonoids: Antioxidants Against Atherosclerosis
title_sort flavonoids: antioxidants against atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257706/
https://www.ncbi.nlm.nih.gov/pubmed/22254061
http://dx.doi.org/10.3390/nu2080889
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