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Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells

Over recent years, several studies have related olive oil ingestion to a low incidence of several diseases, including breast cancer. Hydroxytyrosol and tyrosol are two of the major phenols present in virgin olive oils. Despite the fact that they have been linked to cancer prevention, there is no evi...

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Detalles Bibliográficos
Autores principales: Warleta, Fernando, Quesada, Cristina Sánchez, Campos, María, Allouche, Yosra, Beltrán, Gabriel, Gaforio, José J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257739/
https://www.ncbi.nlm.nih.gov/pubmed/22254082
http://dx.doi.org/10.3390/nu3100839
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author Warleta, Fernando
Quesada, Cristina Sánchez
Campos, María
Allouche, Yosra
Beltrán, Gabriel
Gaforio, José J.
author_facet Warleta, Fernando
Quesada, Cristina Sánchez
Campos, María
Allouche, Yosra
Beltrán, Gabriel
Gaforio, José J.
author_sort Warleta, Fernando
collection PubMed
description Over recent years, several studies have related olive oil ingestion to a low incidence of several diseases, including breast cancer. Hydroxytyrosol and tyrosol are two of the major phenols present in virgin olive oils. Despite the fact that they have been linked to cancer prevention, there is no evidence that clarifies their effect in human breast tumor and non-tumor cells. In the present work, we present hydroxytyrosol and tyrosol’s effects in human breast cell lines. Our results show that hydroxytyrosol acts as a more efficient free radical scavenger than tyrosol, but both fail to affect cell proliferation rates, cell cycle profile or cell apoptosis in human mammary epithelial cells (MCF10A) or breast cancer cells (MDA-MB-231 and MCF7). We found that hydroxytyrosol decreases the intracellular reactive oxygen species (ROS) level in MCF10A cells but not in MCF7 or MDA-MB-231 cells while very high amounts of tyrosol is needed to decrease the ROS level in MCF10A cells. Interestingly, hydroxytyrosol prevents oxidative DNA damage in the three breast cell lines. Therefore, our data suggest that simple phenol hydroxytyrosol could contribute to a lower incidence of breast cancer in populations that consume virgin olive oil due to its antioxidant activity and its protection against oxidative DNA damage in mammary cells.
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spelling pubmed-32577392012-01-17 Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells Warleta, Fernando Quesada, Cristina Sánchez Campos, María Allouche, Yosra Beltrán, Gabriel Gaforio, José J. Nutrients Article Over recent years, several studies have related olive oil ingestion to a low incidence of several diseases, including breast cancer. Hydroxytyrosol and tyrosol are two of the major phenols present in virgin olive oils. Despite the fact that they have been linked to cancer prevention, there is no evidence that clarifies their effect in human breast tumor and non-tumor cells. In the present work, we present hydroxytyrosol and tyrosol’s effects in human breast cell lines. Our results show that hydroxytyrosol acts as a more efficient free radical scavenger than tyrosol, but both fail to affect cell proliferation rates, cell cycle profile or cell apoptosis in human mammary epithelial cells (MCF10A) or breast cancer cells (MDA-MB-231 and MCF7). We found that hydroxytyrosol decreases the intracellular reactive oxygen species (ROS) level in MCF10A cells but not in MCF7 or MDA-MB-231 cells while very high amounts of tyrosol is needed to decrease the ROS level in MCF10A cells. Interestingly, hydroxytyrosol prevents oxidative DNA damage in the three breast cell lines. Therefore, our data suggest that simple phenol hydroxytyrosol could contribute to a lower incidence of breast cancer in populations that consume virgin olive oil due to its antioxidant activity and its protection against oxidative DNA damage in mammary cells. MDPI 2011-10-13 /pmc/articles/PMC3257739/ /pubmed/22254082 http://dx.doi.org/10.3390/nu3100839 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Warleta, Fernando
Quesada, Cristina Sánchez
Campos, María
Allouche, Yosra
Beltrán, Gabriel
Gaforio, José J.
Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title_full Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title_fullStr Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title_full_unstemmed Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title_short Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
title_sort hydroxytyrosol protects against oxidative dna damage in human breast cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257739/
https://www.ncbi.nlm.nih.gov/pubmed/22254082
http://dx.doi.org/10.3390/nu3100839
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