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Polymerization and nucleic acid-binding properties of human L1 ORF1 protein

The L1 (LINE 1) retrotransposable element encodes two proteins, ORF1p and ORF2p. ORF2p is the L1 replicase, but the role of ORF1p is unknown. Mouse ORF1p, a coiled-coil-mediated trimer of ∼42-kDa monomers, binds nucleic acids and has nucleic acid chaperone activity. We purified human L1 ORF1p expres...

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Detalles Bibliográficos
Autores principales:	Callahan, Kathryn E., Hickman, Alison B., Jones, Charles E., Ghirlando, Rodolfo, Furano, Anthony V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258132/ https://www.ncbi.nlm.nih.gov/pubmed/21937507 http://dx.doi.org/10.1093/nar/gkr728

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