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ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

DNA double-strand breaks (DSBs) threaten genome stability in all kingdoms of life and are linked to cancerogenic chromosome aberrations in humans. The Mre11:Rad50 (MR) complex is an evolutionarily conserved complex of two Rad50 ATPases and a dimer of the Mre11 nuclease that senses and processes DSBs...

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Detalles Bibliográficos
Autores principales:	Möckel, Carolin, Lammens, Katja, Schele, Alexandra, Hopfner, Karl-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258140/ https://www.ncbi.nlm.nih.gov/pubmed/21937514 http://dx.doi.org/10.1093/nar/gkr749

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