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Function and disruption of DNA Methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation

The catalytic domain of Dnmt3a cooperatively multimerizes on DNA forming nucleoprotein filaments. Based on modeling, we identified the interface of Dnmt3a complexes binding next to each other on the DNA and disrupted it by charge reversal of critical residues. This prevented cooperative DNA binding...

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Detalles Bibliográficos
Autores principales:	Rajavelu, Arumugam, Jurkowska, Renata Z., Fritz, Jürgen, Jeltsch, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258144/ https://www.ncbi.nlm.nih.gov/pubmed/21926161 http://dx.doi.org/10.1093/nar/gkr753

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