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Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases

Deadenylation is the first and rate-limiting step during turnover of mRNAs in eukaryotes. In the yeast, Saccharomyces cerevisiae, two distinct 3′–5′ exonucleases, Pop2p and Ccr4p, have been identified within the Ccr4-NOT deadenylase complex, belonging to the DEDD and Exonuclease–Endonuclease–Phospha...

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Detalles Bibliográficos
Autores principales:	Feddersen, Ane, Dedic, Emil, Poulsen, Esben G., Schmid, Manfred, Van, Lan Bich, Jensen, Torben Heick, Brodersen, Ditlev E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258157/ https://www.ncbi.nlm.nih.gov/pubmed/21965533 http://dx.doi.org/10.1093/nar/gkr782

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