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Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast

Chromosome ends, known as telomeres, have to be distinguished from DNA double-strand breaks that activate DNA damage checkpoints. In budding yeast, the Mre11-Rad50-Xrs2 (MRX) complex associates with DNA ends and promotes checkpoint activation. Rap1 binds to double-stranded telomeric regions and recr...

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Detalles Bibliográficos
Autores principales:	Fukunaga, Kenzo, Hirano, Yukinori, Sugimoto, Katsunori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258178/ https://www.ncbi.nlm.nih.gov/pubmed/22130795 http://dx.doi.org/10.1091/mbc.E11-06-0568

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