Cargando…
In vitro activities of natural products against oral Candida isolates from denture wearers
BACKGROUND: Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils. METHODS: Eight te...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258290/ https://www.ncbi.nlm.nih.gov/pubmed/22118215 http://dx.doi.org/10.1186/1472-6882-11-119 |
_version_ | 1782221265597104128 |
---|---|
author | Marcos-Arias, Cristina Eraso, Elena Madariaga, Lucila Quindós, Guillermo |
author_facet | Marcos-Arias, Cristina Eraso, Elena Madariaga, Lucila Quindós, Guillermo |
author_sort | Marcos-Arias, Cristina |
collection | PubMed |
description | BACKGROUND: Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils. METHODS: Eight terpenic derivatives (carvacrol, farnesol, geraniol, linalool, menthol, menthone, terpinen-4-ol, and α-terpineol), a phenylpropanoid (eugenol), a phenethyl alcohol (tyrosol) and fluconazole were evaluated against 38 Candida isolated from denture-wearers and 10 collection Candida strains by the CLSI M27-A3 broth microdilution method. RESULTS: Almost all the tested compounds showed antifungal activity with MIC ranges of 0.03-0.25% for eugenol and linalool, 0.03-0.12% for geraniol, 0.06-0.5% for menthol, α-terpineol and terpinen-4-ol, 0.03-0.5% for carvacrol, and 0.06-4% for menthone. These compounds, with the exception of farnesol, menthone and tyrosol, showed important in vitro activities against the fluconazole-resistant and susceptible-dose dependent Candida isolates. CONCLUSIONS: Carvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Their fungistatic and fungicidal activities might convert them into promising alternatives for the topic treatment of oral candidiasis and denture stomatitis. |
format | Online Article Text |
id | pubmed-3258290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32582902012-01-14 In vitro activities of natural products against oral Candida isolates from denture wearers Marcos-Arias, Cristina Eraso, Elena Madariaga, Lucila Quindós, Guillermo BMC Complement Altern Med Research Article BACKGROUND: Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils. METHODS: Eight terpenic derivatives (carvacrol, farnesol, geraniol, linalool, menthol, menthone, terpinen-4-ol, and α-terpineol), a phenylpropanoid (eugenol), a phenethyl alcohol (tyrosol) and fluconazole were evaluated against 38 Candida isolated from denture-wearers and 10 collection Candida strains by the CLSI M27-A3 broth microdilution method. RESULTS: Almost all the tested compounds showed antifungal activity with MIC ranges of 0.03-0.25% for eugenol and linalool, 0.03-0.12% for geraniol, 0.06-0.5% for menthol, α-terpineol and terpinen-4-ol, 0.03-0.5% for carvacrol, and 0.06-4% for menthone. These compounds, with the exception of farnesol, menthone and tyrosol, showed important in vitro activities against the fluconazole-resistant and susceptible-dose dependent Candida isolates. CONCLUSIONS: Carvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Their fungistatic and fungicidal activities might convert them into promising alternatives for the topic treatment of oral candidiasis and denture stomatitis. BioMed Central 2011-11-26 /pmc/articles/PMC3258290/ /pubmed/22118215 http://dx.doi.org/10.1186/1472-6882-11-119 Text en Copyright ©2011 Marcos-Arias et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Marcos-Arias, Cristina Eraso, Elena Madariaga, Lucila Quindós, Guillermo In vitro activities of natural products against oral Candida isolates from denture wearers |
title | In vitro activities of natural products against oral Candida isolates from denture wearers |
title_full | In vitro activities of natural products against oral Candida isolates from denture wearers |
title_fullStr | In vitro activities of natural products against oral Candida isolates from denture wearers |
title_full_unstemmed | In vitro activities of natural products against oral Candida isolates from denture wearers |
title_short | In vitro activities of natural products against oral Candida isolates from denture wearers |
title_sort | in vitro activities of natural products against oral candida isolates from denture wearers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258290/ https://www.ncbi.nlm.nih.gov/pubmed/22118215 http://dx.doi.org/10.1186/1472-6882-11-119 |
work_keys_str_mv | AT marcosariascristina invitroactivitiesofnaturalproductsagainstoralcandidaisolatesfromdenturewearers AT erasoelena invitroactivitiesofnaturalproductsagainstoralcandidaisolatesfromdenturewearers AT madariagalucila invitroactivitiesofnaturalproductsagainstoralcandidaisolatesfromdenturewearers AT quindosguillermo invitroactivitiesofnaturalproductsagainstoralcandidaisolatesfromdenturewearers |