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Chlamydia infection status, genotype, and age-related macular degeneration

PURPOSE: To evaluate whether Chlamydia (C.) infections are associated with age-related macular degeneration (AMD) and to assess if this association is influenced by the complement factor H (CFH) Y402H or the high temperature requirement A serine peptidase 1 (HTRA1) rs11200638 risk genotypes. METHODS...

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Autores principales: Khandhadia, Sam, Foster, Sebastian, Cree, Angela, Griffiths, Helen, Osmond, Clive, Goverdhan, Srinivas, Lotery, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258520/
https://www.ncbi.nlm.nih.gov/pubmed/22259222
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author Khandhadia, Sam
Foster, Sebastian
Cree, Angela
Griffiths, Helen
Osmond, Clive
Goverdhan, Srinivas
Lotery, Andrew
author_facet Khandhadia, Sam
Foster, Sebastian
Cree, Angela
Griffiths, Helen
Osmond, Clive
Goverdhan, Srinivas
Lotery, Andrew
author_sort Khandhadia, Sam
collection PubMed
description PURPOSE: To evaluate whether Chlamydia (C.) infections are associated with age-related macular degeneration (AMD) and to assess if this association is influenced by the complement factor H (CFH) Y402H or the high temperature requirement A serine peptidase 1 (HTRA1) rs11200638 risk genotypes. METHODS: One hundred ninety-nine AMD patients with early and late forms of the disease and 100 unaffected controls, at least 50 years old were included in the study. Patients in the AMD and control groups were selected based on known CFH Y402H variant genotype status (one third homozygous CC, one third heterozygous CT, and one third wild-type TT). Plasma from all patients and controls was tested for C. pneumoniae, C. trachomatis, and C. psittaci IgG seropositivity using a micro-immunofluorescent assay to establish previous infection status. Assays were conducted blind to risk genotypes and the results analyzed using univariate and multivariate (logistic regression) analysis. RESULTS: IgG seropositivity to C. pneumoniae was most prevalent (69.2%, n=207), followed by C. trachomatis (7.4%, n=22) and C. psittaci (3.3%, n=10). No association was found between each of the three Chlamydia species IgG seropositivity and AMD status or severity (early/late). There was also no significant association between Chlamydia species IgG seropositivity and AMD status or severity, in patients carrying at least one CFH Y402H risk allele (C) or HTRA1 rs11200638 risk allele (A), with univariate or logistic regression analysis. CONCLUSIONS: Chlamydia infection status does not appear to be associated with AMD status or severity. The presence of CFH Y402H and HTRA1 rs11200638 risk genotypes does not alter this negative association.
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spelling pubmed-32585202012-01-18 Chlamydia infection status, genotype, and age-related macular degeneration Khandhadia, Sam Foster, Sebastian Cree, Angela Griffiths, Helen Osmond, Clive Goverdhan, Srinivas Lotery, Andrew Mol Vis Research Article PURPOSE: To evaluate whether Chlamydia (C.) infections are associated with age-related macular degeneration (AMD) and to assess if this association is influenced by the complement factor H (CFH) Y402H or the high temperature requirement A serine peptidase 1 (HTRA1) rs11200638 risk genotypes. METHODS: One hundred ninety-nine AMD patients with early and late forms of the disease and 100 unaffected controls, at least 50 years old were included in the study. Patients in the AMD and control groups were selected based on known CFH Y402H variant genotype status (one third homozygous CC, one third heterozygous CT, and one third wild-type TT). Plasma from all patients and controls was tested for C. pneumoniae, C. trachomatis, and C. psittaci IgG seropositivity using a micro-immunofluorescent assay to establish previous infection status. Assays were conducted blind to risk genotypes and the results analyzed using univariate and multivariate (logistic regression) analysis. RESULTS: IgG seropositivity to C. pneumoniae was most prevalent (69.2%, n=207), followed by C. trachomatis (7.4%, n=22) and C. psittaci (3.3%, n=10). No association was found between each of the three Chlamydia species IgG seropositivity and AMD status or severity (early/late). There was also no significant association between Chlamydia species IgG seropositivity and AMD status or severity, in patients carrying at least one CFH Y402H risk allele (C) or HTRA1 rs11200638 risk allele (A), with univariate or logistic regression analysis. CONCLUSIONS: Chlamydia infection status does not appear to be associated with AMD status or severity. The presence of CFH Y402H and HTRA1 rs11200638 risk genotypes does not alter this negative association. Molecular Vision 2012-01-10 /pmc/articles/PMC3258520/ /pubmed/22259222 Text en Copyright © 2012 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khandhadia, Sam
Foster, Sebastian
Cree, Angela
Griffiths, Helen
Osmond, Clive
Goverdhan, Srinivas
Lotery, Andrew
Chlamydia infection status, genotype, and age-related macular degeneration
title Chlamydia infection status, genotype, and age-related macular degeneration
title_full Chlamydia infection status, genotype, and age-related macular degeneration
title_fullStr Chlamydia infection status, genotype, and age-related macular degeneration
title_full_unstemmed Chlamydia infection status, genotype, and age-related macular degeneration
title_short Chlamydia infection status, genotype, and age-related macular degeneration
title_sort chlamydia infection status, genotype, and age-related macular degeneration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258520/
https://www.ncbi.nlm.nih.gov/pubmed/22259222
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