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Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

PURPOSE: Tyrosinase is the rate-limiting enzyme responsible for melanin biosynthesis in the retinal pigment epithelium (RPE) of the eye. Melanin has an important role in retinal development, function, and protection against light-induced oxidative stress, and melanin levels are associated with age-r...

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Detalles Bibliográficos
Autores principales:	Reinisalo, Mika, Putula, Jaana, Mannermaa, Eliisa, Urtti, Arto, Honkakoski, Paavo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258524/ https://www.ncbi.nlm.nih.gov/pubmed/22259223

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