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Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment
Clinically obvious reasons why children with neurological impairment (NMI) may be more severely affected in case of a viral respiratory tract infection include reduced vital capacity due to muscular weakness or spastic scoliosis, disturbed clearance of respiratory excretions (weak coughing and dysph...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258658/ https://www.ncbi.nlm.nih.gov/pubmed/22262988 http://dx.doi.org/10.2174/1874285801105010155 |
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author | Simon, Arne Prusseit, Julia Müller, Andreas |
author_facet | Simon, Arne Prusseit, Julia Müller, Andreas |
author_sort | Simon, Arne |
collection | PubMed |
description | Clinically obvious reasons why children with neurological impairment (NMI) may be more severely affected in case of a viral respiratory tract infection include reduced vital capacity due to muscular weakness or spastic scoliosis, disturbed clearance of respiratory excretions (weak coughing and dysphagia), inability to comply actively with physiotherapeutic interventions, recurrent micro-aspirations (gastroesophageal reflux disease, vomiting related to coughing), a history of frequent exposure to antibiotics and health care institutions, colonization with resistant pathogens, impaired immunologic defence mechanisms due to severe malnutrition and cachexia, and early clinical deterioration in case of high fever with metabolic acidosis and hypercapnia, and maybe associated seizures or febrile convulsions. Data from the literature suggests that in all children with NMI, who have to be hospitalized with severe clinical deterioration due to an airway infection, at least one specimen of nasopharyngeal secretions should be sent as soon as possible to a virologic laboratory to detect viral pathogens. Children with severe NMI and those mechanically ventilated for other reasons being hospitalized during the RSV season must be strictly protected against nosocomial RSV infection by means of standard and droplet precautions. Finally, children with severe NMI and age below 24 months of life should receive passive immunization with palivizumab following international recommendations. |
format | Online Article Text |
id | pubmed-3258658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-32586582012-01-19 Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment Simon, Arne Prusseit, Julia Müller, Andreas Open Microbiol J Article Clinically obvious reasons why children with neurological impairment (NMI) may be more severely affected in case of a viral respiratory tract infection include reduced vital capacity due to muscular weakness or spastic scoliosis, disturbed clearance of respiratory excretions (weak coughing and dysphagia), inability to comply actively with physiotherapeutic interventions, recurrent micro-aspirations (gastroesophageal reflux disease, vomiting related to coughing), a history of frequent exposure to antibiotics and health care institutions, colonization with resistant pathogens, impaired immunologic defence mechanisms due to severe malnutrition and cachexia, and early clinical deterioration in case of high fever with metabolic acidosis and hypercapnia, and maybe associated seizures or febrile convulsions. Data from the literature suggests that in all children with NMI, who have to be hospitalized with severe clinical deterioration due to an airway infection, at least one specimen of nasopharyngeal secretions should be sent as soon as possible to a virologic laboratory to detect viral pathogens. Children with severe NMI and those mechanically ventilated for other reasons being hospitalized during the RSV season must be strictly protected against nosocomial RSV infection by means of standard and droplet precautions. Finally, children with severe NMI and age below 24 months of life should receive passive immunization with palivizumab following international recommendations. Bentham Open 2011-12-30 /pmc/articles/PMC3258658/ /pubmed/22262988 http://dx.doi.org/10.2174/1874285801105010155 Text en © Simon et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Simon, Arne Prusseit, Julia Müller, Andreas Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title | Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title_full | Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title_fullStr | Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title_full_unstemmed | Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title_short | Respiratory Syncytial Virus Infection in Children with Neuromuscular Impairment |
title_sort | respiratory syncytial virus infection in children with neuromuscular impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258658/ https://www.ncbi.nlm.nih.gov/pubmed/22262988 http://dx.doi.org/10.2174/1874285801105010155 |
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