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The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study

INTRODUCTION: Luteal phase support in assisted reproductive technology (ART) cycles is still controversial. The present study was conducted to evaluate the effect of adding oral oestradiol to progesterone during ART cycles. MATERIAL AND METHODS: In this prospective case control study, infertile wome...

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Autores principales: Moini, Ashraf, Zadeh Modarress, Shahrzad, Amirchaghmaghi, Elham, Mirghavam, Naeimeh, Khafri, Soraya, Reza Akhoond, Mohammad, Salman Yazdi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258705/
https://www.ncbi.nlm.nih.gov/pubmed/22291742
http://dx.doi.org/10.5114/aoms.2011.20613
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author Moini, Ashraf
Zadeh Modarress, Shahrzad
Amirchaghmaghi, Elham
Mirghavam, Naeimeh
Khafri, Soraya
Reza Akhoond, Mohammad
Salman Yazdi, Reza
author_facet Moini, Ashraf
Zadeh Modarress, Shahrzad
Amirchaghmaghi, Elham
Mirghavam, Naeimeh
Khafri, Soraya
Reza Akhoond, Mohammad
Salman Yazdi, Reza
author_sort Moini, Ashraf
collection PubMed
description INTRODUCTION: Luteal phase support in assisted reproductive technology (ART) cycles is still controversial. The present study was conducted to evaluate the effect of adding oral oestradiol to progesterone during ART cycles. MATERIAL AND METHODS: In this prospective case control study, infertile women under 35 years old who were candidates for IVF/ICSI cycles in Royan Institute were enrolled. A long gonadotropin-releasing hormone (GnRH) agonist protocol was used for ovarian stimulation. Patients were randomly divided into two groups for luteal phase support: the control group received vaginal administration of progesterone supplementation alone starting on the day after oocyte retrieval and continued until the tenth week if the chemical pregnancy test was positive. In the oestradiol group, 2 mg of oestradiol valerate was initiated orally with progesterone. The control group received a placebo instead of oestradiol. RESULTS: Ninety-eight women were studied as oestradiol (N = 47) and control groups (N= 51). There were no significant differences in the mean number of retrieved oocytes, number of transferred embryos, or chemical and clinical pregnancy rates between the two groups. Although the serum progesterone concentration was higher in the oestradiol group in comparison to the control group on day 7, 10 and 12 after embryo transfer, these differences were not statistically significant. CONCLUSIONS: The results suggested that adding oral oestradiol to vaginal progesterone supplementation does not improve the chemical and clinical pregnancy rates of IVF/ICSI cycles.
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spelling pubmed-32587052012-01-30 The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study Moini, Ashraf Zadeh Modarress, Shahrzad Amirchaghmaghi, Elham Mirghavam, Naeimeh Khafri, Soraya Reza Akhoond, Mohammad Salman Yazdi, Reza Arch Med Sci Clinical Research INTRODUCTION: Luteal phase support in assisted reproductive technology (ART) cycles is still controversial. The present study was conducted to evaluate the effect of adding oral oestradiol to progesterone during ART cycles. MATERIAL AND METHODS: In this prospective case control study, infertile women under 35 years old who were candidates for IVF/ICSI cycles in Royan Institute were enrolled. A long gonadotropin-releasing hormone (GnRH) agonist protocol was used for ovarian stimulation. Patients were randomly divided into two groups for luteal phase support: the control group received vaginal administration of progesterone supplementation alone starting on the day after oocyte retrieval and continued until the tenth week if the chemical pregnancy test was positive. In the oestradiol group, 2 mg of oestradiol valerate was initiated orally with progesterone. The control group received a placebo instead of oestradiol. RESULTS: Ninety-eight women were studied as oestradiol (N = 47) and control groups (N= 51). There were no significant differences in the mean number of retrieved oocytes, number of transferred embryos, or chemical and clinical pregnancy rates between the two groups. Although the serum progesterone concentration was higher in the oestradiol group in comparison to the control group on day 7, 10 and 12 after embryo transfer, these differences were not statistically significant. CONCLUSIONS: The results suggested that adding oral oestradiol to vaginal progesterone supplementation does not improve the chemical and clinical pregnancy rates of IVF/ICSI cycles. Termedia Publishing House 2011-02 2011-03-08 /pmc/articles/PMC3258705/ /pubmed/22291742 http://dx.doi.org/10.5114/aoms.2011.20613 Text en Copyright © 2011 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Moini, Ashraf
Zadeh Modarress, Shahrzad
Amirchaghmaghi, Elham
Mirghavam, Naeimeh
Khafri, Soraya
Reza Akhoond, Mohammad
Salman Yazdi, Reza
The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title_full The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title_fullStr The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title_full_unstemmed The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title_short The effect of adding oral oestradiol to progesterone as luteal phase support in ART cycles – a randomized controlled study
title_sort effect of adding oral oestradiol to progesterone as luteal phase support in art cycles – a randomized controlled study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258705/
https://www.ncbi.nlm.nih.gov/pubmed/22291742
http://dx.doi.org/10.5114/aoms.2011.20613
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