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Association between atherosclerosis and osteoporosis, the role of vitamin D

The latest data support the correlation of atherosclerosis and osteoporosis, indicating the parallel progression of two tissue destruction processes with increased fatal and non-fatal coronary events, as well as higher fracture risk. Vitamin D inadequacy associated with low bone mineral density incr...

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Detalles Bibliográficos
Autores principales: Stojanovic, Olivera Ilić, Lazovic, Milica, Lazovic, Marko, Vuceljic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258717/
https://www.ncbi.nlm.nih.gov/pubmed/22291755
http://dx.doi.org/10.5114/aoms.2011.22066
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author Stojanovic, Olivera Ilić
Lazovic, Milica
Lazovic, Marko
Vuceljic, Marina
author_facet Stojanovic, Olivera Ilić
Lazovic, Milica
Lazovic, Marko
Vuceljic, Marina
author_sort Stojanovic, Olivera Ilić
collection PubMed
description The latest data support the correlation of atherosclerosis and osteoporosis, indicating the parallel progression of two tissue destruction processes with increased fatal and non-fatal coronary events, as well as higher fracture risk. Vitamin D inadequacy associated with low bone mineral density increases fall and fracture risk, leads to secondary hyperparathyroidism, calcifies coronary arteries and significantly increases cardiovascular disease. Randomized clinical trial evidence related to extraskeletal vitamin D outcomes was limited and generally uninformative. A recent recommendation on vitamin D dietary requirements for bone health is 600 IU/d for ages 1-70 years and 800 IU/d for 71 years and older, corresponding to a serum 25-hydroxyvitamin D level of at least 20 ng/ml (50 nmol/l). Further large randomized controlled trials are needed to reassess laboratory ranges for 25-hydroxyvitamin D in both diseases, in order to avoid under- and over-treatment problems, and completely clarify the relationship between atherosclerosis and osteoporosis.
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spelling pubmed-32587172012-01-30 Association between atherosclerosis and osteoporosis, the role of vitamin D Stojanovic, Olivera Ilić Lazovic, Milica Lazovic, Marko Vuceljic, Marina Arch Med Sci Review Paper The latest data support the correlation of atherosclerosis and osteoporosis, indicating the parallel progression of two tissue destruction processes with increased fatal and non-fatal coronary events, as well as higher fracture risk. Vitamin D inadequacy associated with low bone mineral density increases fall and fracture risk, leads to secondary hyperparathyroidism, calcifies coronary arteries and significantly increases cardiovascular disease. Randomized clinical trial evidence related to extraskeletal vitamin D outcomes was limited and generally uninformative. A recent recommendation on vitamin D dietary requirements for bone health is 600 IU/d for ages 1-70 years and 800 IU/d for 71 years and older, corresponding to a serum 25-hydroxyvitamin D level of at least 20 ng/ml (50 nmol/l). Further large randomized controlled trials are needed to reassess laboratory ranges for 25-hydroxyvitamin D in both diseases, in order to avoid under- and over-treatment problems, and completely clarify the relationship between atherosclerosis and osteoporosis. Termedia Publishing House 2011-04 2011-05-17 /pmc/articles/PMC3258717/ /pubmed/22291755 http://dx.doi.org/10.5114/aoms.2011.22066 Text en Copyright © 2011 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Paper
Stojanovic, Olivera Ilić
Lazovic, Milica
Lazovic, Marko
Vuceljic, Marina
Association between atherosclerosis and osteoporosis, the role of vitamin D
title Association between atherosclerosis and osteoporosis, the role of vitamin D
title_full Association between atherosclerosis and osteoporosis, the role of vitamin D
title_fullStr Association between atherosclerosis and osteoporosis, the role of vitamin D
title_full_unstemmed Association between atherosclerosis and osteoporosis, the role of vitamin D
title_short Association between atherosclerosis and osteoporosis, the role of vitamin D
title_sort association between atherosclerosis and osteoporosis, the role of vitamin d
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258717/
https://www.ncbi.nlm.nih.gov/pubmed/22291755
http://dx.doi.org/10.5114/aoms.2011.22066
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