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Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome

INTRODUCTION: Previous studies have shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. MATERIAL AND METHODS: We investigated the relationship between plasma N-terminal pro-B-t...

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Autores principales: Bao, Yuanyuan, Shang, Xiliang, Zhou, Linuo, Hu, Renming, Li, Yiming, Ding, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258734/
https://www.ncbi.nlm.nih.gov/pubmed/22291764
http://dx.doi.org/10.5114/aoms.2011.22075
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author Bao, Yuanyuan
Shang, Xiliang
Zhou, Linuo
Hu, Renming
Li, Yiming
Ding, Wei
author_facet Bao, Yuanyuan
Shang, Xiliang
Zhou, Linuo
Hu, Renming
Li, Yiming
Ding, Wei
author_sort Bao, Yuanyuan
collection PubMed
description INTRODUCTION: Previous studies have shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. MATERIAL AND METHODS: We investigated the relationship between plasma N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) and metabolic syndrome (MetS) and metabolic risk factors in 469 patients free of heart failure. Two hundred thirty diagnosed MetS cases and 239 non-MetS cases were included in this study. Echocardiography examinations were performed and left ventricular mass index was calculated according to the Devereux correction formula. NT-proBNP was measured by electrochemiluminescence. The log-transformed NT-proBNP levels were used for abnormal distribution. Multiple linear regression analysis was performed to assess the association between levels of NT-proBNP and metabolic factors. Covariance analysis was used for group comparisons. RESULTS: Log NT-proBNP levels were independently related to age, gender, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, left ventricular mass index and left ventricular ejection fraction in multiple linear regression analysis (p < 0.05). Adjusted log NT-proBNP levels were lower in persons with MetS compared with those without MetS (p < 0.05). Individuals with hyperlipidaemia, elevated body mass index, diastolic blood pressure and fasting plasma glucose had lower levels of log NT-proBNP than those without MetS (p < 0.05). CONCLUSIONS: There is a relationship between metabolic components and lower plasma NT-proBNP concentration. These findings raise the possibility that reduced plasma NT-proBNP levels are a manifestation of MetS, which might possess significant clinical and pathophysiological implications.
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spelling pubmed-32587342012-01-30 Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome Bao, Yuanyuan Shang, Xiliang Zhou, Linuo Hu, Renming Li, Yiming Ding, Wei Arch Med Sci Clinical Research INTRODUCTION: Previous studies have shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. MATERIAL AND METHODS: We investigated the relationship between plasma N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) and metabolic syndrome (MetS) and metabolic risk factors in 469 patients free of heart failure. Two hundred thirty diagnosed MetS cases and 239 non-MetS cases were included in this study. Echocardiography examinations were performed and left ventricular mass index was calculated according to the Devereux correction formula. NT-proBNP was measured by electrochemiluminescence. The log-transformed NT-proBNP levels were used for abnormal distribution. Multiple linear regression analysis was performed to assess the association between levels of NT-proBNP and metabolic factors. Covariance analysis was used for group comparisons. RESULTS: Log NT-proBNP levels were independently related to age, gender, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, left ventricular mass index and left ventricular ejection fraction in multiple linear regression analysis (p < 0.05). Adjusted log NT-proBNP levels were lower in persons with MetS compared with those without MetS (p < 0.05). Individuals with hyperlipidaemia, elevated body mass index, diastolic blood pressure and fasting plasma glucose had lower levels of log NT-proBNP than those without MetS (p < 0.05). CONCLUSIONS: There is a relationship between metabolic components and lower plasma NT-proBNP concentration. These findings raise the possibility that reduced plasma NT-proBNP levels are a manifestation of MetS, which might possess significant clinical and pathophysiological implications. Termedia Publishing House 2011-04 2011-05-17 /pmc/articles/PMC3258734/ /pubmed/22291764 http://dx.doi.org/10.5114/aoms.2011.22075 Text en Copyright © 2011 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Bao, Yuanyuan
Shang, Xiliang
Zhou, Linuo
Hu, Renming
Li, Yiming
Ding, Wei
Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title_full Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title_fullStr Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title_full_unstemmed Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title_short Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome
title_sort relationship between n-terminal pro-b-type natriuretic peptide levels and metabolic syndrome
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258734/
https://www.ncbi.nlm.nih.gov/pubmed/22291764
http://dx.doi.org/10.5114/aoms.2011.22075
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