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The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles
INTRODUCTION: Ovarian stimulation is employed in assisted reproduction techniques in order to obtain as many oocytes as possible. The early rise in oestradiol levels may lead to the premature end of the respective cycle. In order to avoid such an effect, pituitary suppression has been employed. The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Termedia Publishing House
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258761/ https://www.ncbi.nlm.nih.gov/pubmed/22295031 http://dx.doi.org/10.5114/aoms.2011.23414 |
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author | Cavagna, Mario Paes de Almeida Ferreira Braga, Daniela Biaggioni Lopes, Fabio de Cássia Savio Figueira, Rita Iaconelli, Assumpto Borges, Edson |
author_facet | Cavagna, Mario Paes de Almeida Ferreira Braga, Daniela Biaggioni Lopes, Fabio de Cássia Savio Figueira, Rita Iaconelli, Assumpto Borges, Edson |
author_sort | Cavagna, Mario |
collection | PubMed |
description | INTRODUCTION: Ovarian stimulation is employed in assisted reproduction techniques in order to obtain as many oocytes as possible. The early rise in oestradiol levels may lead to the premature end of the respective cycle. In order to avoid such an effect, pituitary suppression has been employed. The aim of this study was to evaluate whether maintenance or replacement of the type of GnRH analogue (i.e., agonist or antagonist) employed for pituitary suppression in the consecutive intracytoplasmic sperm injection (ICSI) cycle would negatively influence oocyte quality and ICSI outcome. MATERIAL AND METHODS: A retrospective observational study was conducted including 181 women with primary infertility. Patients were divided into four different groups according to the GnRH analogue used for pituitary suppression in the first and consecutive cycle. RESULTS: When a GnRH agonist was employed for pituitary suppression in the first cycle, the consecutive cycle showed comparable outcomes when performed with either a GnRH agonist or a GnRH antagonist. When the first cycle was performed with a GnRH antagonist, the use of the GnRH agonist in the successive cycle led to an increased number of oocytes retrieved (7.5% vs. 10.3%, p = 0.032) and the production of a higher number of embryos (4.5% vs. 6.3%, p = 0.036). CONCLUSIONS: When the first cycle is carried out with a GnRH antagonist, the use of a GnRH agonist in the successive cycle would lead to increased numbers of oocytes collected and embryos produced. |
format | Online Article Text |
id | pubmed-3258761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-32587612012-01-31 The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles Cavagna, Mario Paes de Almeida Ferreira Braga, Daniela Biaggioni Lopes, Fabio de Cássia Savio Figueira, Rita Iaconelli, Assumpto Borges, Edson Arch Med Sci Clinical Research INTRODUCTION: Ovarian stimulation is employed in assisted reproduction techniques in order to obtain as many oocytes as possible. The early rise in oestradiol levels may lead to the premature end of the respective cycle. In order to avoid such an effect, pituitary suppression has been employed. The aim of this study was to evaluate whether maintenance or replacement of the type of GnRH analogue (i.e., agonist or antagonist) employed for pituitary suppression in the consecutive intracytoplasmic sperm injection (ICSI) cycle would negatively influence oocyte quality and ICSI outcome. MATERIAL AND METHODS: A retrospective observational study was conducted including 181 women with primary infertility. Patients were divided into four different groups according to the GnRH analogue used for pituitary suppression in the first and consecutive cycle. RESULTS: When a GnRH agonist was employed for pituitary suppression in the first cycle, the consecutive cycle showed comparable outcomes when performed with either a GnRH agonist or a GnRH antagonist. When the first cycle was performed with a GnRH antagonist, the use of the GnRH agonist in the successive cycle led to an increased number of oocytes retrieved (7.5% vs. 10.3%, p = 0.032) and the production of a higher number of embryos (4.5% vs. 6.3%, p = 0.036). CONCLUSIONS: When the first cycle is carried out with a GnRH antagonist, the use of a GnRH agonist in the successive cycle would lead to increased numbers of oocytes collected and embryos produced. Termedia Publishing House 2011-06 2011-07-11 /pmc/articles/PMC3258761/ /pubmed/22295031 http://dx.doi.org/10.5114/aoms.2011.23414 Text en Copyright © 2011 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Cavagna, Mario Paes de Almeida Ferreira Braga, Daniela Biaggioni Lopes, Fabio de Cássia Savio Figueira, Rita Iaconelli, Assumpto Borges, Edson The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title | The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title_full | The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title_fullStr | The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title_full_unstemmed | The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title_short | The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
title_sort | effect of gnrh analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cycles |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258761/ https://www.ncbi.nlm.nih.gov/pubmed/22295031 http://dx.doi.org/10.5114/aoms.2011.23414 |
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