Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation

BACKGROUND: Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal carcinoma (CCRCC) progression. However, clinical trials with the prototypic Hsp9...

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Detalles Bibliográficos
Autores principales: Bohonowych, Jessica ES, Peng, Shuping, Gopal, Udhayakumar, Hance, Michael W, Wing, Shane B, Argraves, Kelley M, Lundgren, Karen, Isaacs, Jennifer S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259130/
https://www.ncbi.nlm.nih.gov/pubmed/22172030
http://dx.doi.org/10.1186/1471-2407-11-520

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