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Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test
BACKGROUND: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. METHODS: Male Sprague Dawl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Pain Society
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259131/ https://www.ncbi.nlm.nih.gov/pubmed/22259709 http://dx.doi.org/10.3344/kjp.2012.25.1.1 |
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author | Han, Yong Ku Lee, Seong Heon Jeong, Hye Jin Kim, Min Sun Yoon, Myung Ha Kim, Woong Mo |
author_facet | Han, Yong Ku Lee, Seong Heon Jeong, Hye Jin Kim, Min Sun Yoon, Myung Ha Kim, Woong Mo |
author_sort | Han, Yong Ku |
collection | PubMed |
description | BACKGROUND: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. METHODS: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 µl) into the hind paw. Curcumin doses of 62.5, 125, 250, and 500 µg were delivered through an intrathecal catheter to examine the flinching responses. The ED(50) values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale. RESULTS: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the ED(50) value (95% confidence interval) of curcumin was 511.4 µg (23.5-1126.5). There was no apparent abnormal behavior following the administration of curcumin. CONCLUSIONS: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted. |
format | Online Article Text |
id | pubmed-3259131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Pain Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-32591312012-01-18 Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test Han, Yong Ku Lee, Seong Heon Jeong, Hye Jin Kim, Min Sun Yoon, Myung Ha Kim, Woong Mo Korean J Pain Original Article BACKGROUND: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. METHODS: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 µl) into the hind paw. Curcumin doses of 62.5, 125, 250, and 500 µg were delivered through an intrathecal catheter to examine the flinching responses. The ED(50) values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale. RESULTS: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the ED(50) value (95% confidence interval) of curcumin was 511.4 µg (23.5-1126.5). There was no apparent abnormal behavior following the administration of curcumin. CONCLUSIONS: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted. The Korean Pain Society 2012-01 2012-01-02 /pmc/articles/PMC3259131/ /pubmed/22259709 http://dx.doi.org/10.3344/kjp.2012.25.1.1 Text en Copyright © The Korean Pain Society, 2012 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Han, Yong Ku Lee, Seong Heon Jeong, Hye Jin Kim, Min Sun Yoon, Myung Ha Kim, Woong Mo Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title | Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title_full | Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title_fullStr | Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title_full_unstemmed | Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title_short | Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test |
title_sort | analgesic effects of intrathecal curcumin in the rat formalin test |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259131/ https://www.ncbi.nlm.nih.gov/pubmed/22259709 http://dx.doi.org/10.3344/kjp.2012.25.1.1 |
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