Cargando…

TWIST1 a New Determinant of Epithelial to Mesenchymal Transition in EGFR Mutated Lung Adenocarcinoma

Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with a copy number gain at a locus encompassing the TWIST1 gene on chromosome 7. TWIST1 is a highly conserved developmental gene involved in embryogenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pallier, Karine, Cessot, Anatole, Côté, Jean-Francois, Just, Pierre-Alexandre, Cazes, Aurélie, Fabre, Elizabeth, Danel, Claire, Riquet, Marc, Devouassoux-Shisheboran, Mojgan, Ansieau, Stéphane, Puisieux, Alain, Laurent-Puig, Pierre, Blons, Hélène
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260187/ https://www.ncbi.nlm.nih.gov/pubmed/22272264 http://dx.doi.org/10.1371/journal.pone.0029954

Ejemplares similares

The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells()
por: Jacqueroud, Laurent, et al.
Publicado: (2016)

Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma
por: Blons, Hélène, et al.
Publicado: (2008)

Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer
por: Pécuchet, Nicolas, et al.
Publicado: (2015)

A twist for survival and cancer progression
por: Puisieux, A, et al.
Publicado: (2006)

Modulation of Oxidative Stress by Twist Oncoproteins
por: Floc'h, Nicolas, et al.
Publicado: (2013)

Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach
por: Bouard, Charlotte, et al.
Publicado: (2017)

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice
por: Morel, Anne-Pierre, et al.
Publicado: (2012)

Interhelical loops within the bHLH domain are determinant in maintaining TWIST1–DNA complexes
por: Bouard, Charlotte, et al.
Publicado: (2013)

Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
por: Legras, Antoine, et al.
Publicado: (2017)

Pathobiology of ovarian carcinomas
por: Devouassoux-Shisheboran, Mojgan, et al.
Publicado: (2015)

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses
por: Guyard, Alice, et al.
Publicado: (2017)

Deciphering the molecular mechanisms underlying the binding of the TWIST1/E12 complex to regulatory E-box sequences
por: Bouard, Charlotte, et al.
Publicado: (2016)

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
por: Merindol, N, et al.
Publicado: (2014)

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
por: Merindol, N, et al.
Publicado: (2014)

Should We Consider Cancers as Embryonic Diseases or as Consequences of Stem-Cell Deregulation?
por: Bastid, Jérémy, et al.
Publicado: (2008)

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
por: Morel, Anne-Pierre, et al.
Publicado: (2008)

Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
por: Drouet, Youenn, et al.
Publicado: (2018)

Evaluation of p16/Ki-67 Dual Staining Compared with HPV Genotyping in Anal Cytology with Diagnosis of ASC-US for Detection of High-Grade Anal Intraepithelial Lesions
por: Pichon, Maxime, et al.
Publicado: (2019)

Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming
por: Collin, Guillaume, et al.
Publicado: (2023)

ABCG2, a novel antigen to sort luminal progenitors of BRCA1(-) breast cancer cells
por: Leccia, Felicia, et al.
Publicado: (2014)

Current and Future Molecular Testing in NSCLC, What Can We Expect from New Sequencing Technologies?
por: Garinet, Simon, et al.
Publicado: (2018)

Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?
por: Mansuet-Lupo, Audrey, et al.
Publicado: (2014)

Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors
por: Perrier, Alexandre, et al.
Publicado: (2020)

Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity
por: Uchuya-Castillo, Joel, et al.
Publicado: (2018)

Diagnostic yield and therapeutic impact of open lung biopsy in the critically ill patient
por: Philipponnet, Carole, et al.
Publicado: (2018)

NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas
por: Tlemsani, Camille, et al.
Publicado: (2019)

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers
por: Harlé, A, et al.
Publicado: (2015)

Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study
por: Pécuchet, Nicolas, et al.
Publicado: (2016)

Snail Family Members Unequally Trigger EMT and Thereby Differ in Their Ability to Promote the Neoplastic Transformation of Mammary Epithelial Cells
por: Gras, Baptiste, et al.
Publicado: (2014)

Polypoid endometriosis of the Douglas pouch
por: Jacquot, A, et al.
Publicado: (2020)

KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST
por: Klinke, Olaf Karl, et al.
Publicado: (2015)

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations
por: Zonta, Eleonora, et al.
Publicado: (2016)

Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
por: Collet, Constance, et al.
Publicado: (2021)

Clinical utility of SMARCA4 testing by immunohistochemistry in rare ovarian tumours
por: Genestie, Catherine, et al.
Publicado: (2019)

Is uterine preservation combined with bilateral salpingo-oophorectomy to promote subsequent fertility safe in infiltrative mucinous ovarian cancer?
por: Gouy, Sebastien, et al.
Publicado: (2017)

Staging surgery in early-stage ovarian mucinous tumors according to expansile and infiltrative types
por: Gouy, Sebastien, et al.
Publicado: (2017)

EGFR, KRAS, BRAF, and HER-2 molecular status in brain metastases from 77 NSCLC patients
por: Villalva, Claire, et al.
Publicado: (2013)

Next-Generation Sequencing Targeted Panel in Routine Care for Metastatic Colon Cancers
por: Bayle, Arnaud, et al.
Publicado: (2021)

A novel Chr1-miR-200 driven whole transcriptome signature shapes tumor immune microenvironment and predicts relapse in early-stage lung adenocarcinoma
por: Garinet, Simon, et al.
Publicado: (2023)

Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection
por: Damman, Elise, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s1dqmbr83b8jaq7mp2rfu6fvqg