The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study

Firefly luciferase is one of the few soluble proteins that is acted upon by a wide variety of general anesthetics and alcohols; they inhibit the ATP–driven production of light. We have used time–resolved photolabeling to locate the binding sites of alcohols during the initial light output, some 200...

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Detalles Bibliográficos
Autores principales: Shanmugasundararaj, Sivananthaperumal, Lehle, Simon, Yamodo, Herve I., Husain, S. Shaukat, Tseng, Claire, Nguyen, Khanh, Addona, George H., Miller, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260189/
https://www.ncbi.nlm.nih.gov/pubmed/22272253
http://dx.doi.org/10.1371/journal.pone.0029854

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