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Reactive Oxygen Species Stimulate Insulin Secretion in Rat Pancreatic Islets: Studies Using Mono-Oleoyl-Glycerol

Chronic exposure (24–72 hrs) of pancreatic islets to elevated glucose and fatty acid leads to glucolipoxicity characterized by basal insulin hypersecretion and impaired glucose-stimulated insulin secretion (GSIS). Our aim was to determine the mechanism for basal hypersecretion of insulin. We used mo...

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Detalles Bibliográficos
Autores principales:	Saadeh, Marylana, Ferrante, Thomas C., Kane, Ada, Shirihai, Orian, Corkey, Barbara E., Deeney, Jude T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260220/ https://www.ncbi.nlm.nih.gov/pubmed/22272304 http://dx.doi.org/10.1371/journal.pone.0030200

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