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Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics

Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modification of αA-crystallin increased its chaperone fu...

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Detalles Bibliográficos
Autores principales:	Nagaraj, Ram H., Panda, Alok Kumar, Shanthakumar, Shilpa, Santhoshkumar, Puttur, Pasupuleti, NagaRekha, Wang, Benlian, Biswas, Ashis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260246/ https://www.ncbi.nlm.nih.gov/pubmed/22272318 http://dx.doi.org/10.1371/journal.pone.0030257

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